Harder A, Danneschewski A, Wunderlich F
Business Group Animal Health, Institute of Parasitology, Leverkusen-Bayerwerk, Germany.
J Parasitol. 1995 Oct;81(5):733-5.
The nematode Heterakis spumosa lives and develops in the upper colon of mice. The colon mucosa contains soluble factors that significantly increase release of eggs by female H. spumosa in vitro. Egg release is stimulated more when colon factors are prepared from mice harboring adult H. spumosa. Also, soluble factors stimulating egg release can be prepared from homogenates of H. spumosa but are not contained in H. spumosa-conditioned medium. Moreover, soluble factors from the small intestine of mice infected with Heligmosomoides polygyrus also stimulate egg release by H. spumosa females in vitro to about the same extent as soluble factors from the colon of H. spumosa-infected mice. Our data suggest that colon factors are involved in the regulation of egg deposition of H. spumosa, the efficiency of these factors is increased by intestinal inflammation, and that these factors are accumulated by H. spumosa worms.
线虫泡翼线虫在小鼠的上段结肠中生存和发育。结肠黏膜含有可溶性因子，这些因子在体外能显著增加泡翼线虫雌虫的排卵量。当从携带泡翼线虫成虫的小鼠中制备结肠因子时，排卵受到的刺激更大。此外，刺激排卵的可溶性因子可从泡翼线虫匀浆中制备，但泡翼线虫条件培养基中不含有这些因子。而且，感染多枝细颈线虫的小鼠小肠中的可溶性因子，在体外刺激泡翼线虫雌虫排卵的程度，与泡翼线虫感染小鼠结肠中的可溶性因子大致相同。我们的数据表明，结肠因子参与泡翼线虫排卵的调节，肠道炎症会提高这些因子的效率，并且这些因子会被泡翼线虫积累。
