Feydy A, Carlier R, Vallée C, Mompoint D, Chevallier A, Engerand S, Bhavsar P, Ollivier L
Service d'Imagerie Médicale, Hôpital Raymond-Poincaré, Garches.
J Radiol. 1995 Sep;76(9):561-72.
Carcinomas of the prostate and breast are the most common sources of osteosclerotic metastases. The osteoblastic response is related to stromal bone formation and reactive bone formation. Purely osteosclerotic or mixed osteolytic-osteosclerotic lesions are encountered. Frequent differential diagnoses are enostoses and Paget's disease. The classical MRI pattern is a signal of low intensity on T1 and T2- weighted sequences, but some osteoblastic metastases have an inhomogenous signal. Evaluation of the response to treatment is difficult and requires confrontation with clinical and biological data.
前列腺癌和乳腺癌是骨硬化转移最常见的来源。成骨细胞反应与基质骨形成和反应性骨形成有关。会出现单纯的骨硬化或溶骨-骨硬化混合性病变。常见的鉴别诊断包括骨岛和佩吉特病。典型的磁共振成像（MRI）表现是在T1加权和T2加权序列上呈低信号，但一些成骨细胞转移灶信号不均匀。评估治疗反应很困难，需要结合临床和生物学数据。
