Coll J, Tomás S, Vilella R, Corominas J
Department of Medicine, Hospital del Mar, Universidad Autónoma de Barcelona, Spain.
J Rheumatol. 1995 Aug;22(8):1488-91.
To study interleukin-2 receptor (IL-2R) expression in lymphocytic and epithelial cells in salivary glands of patients with Sjögren's syndrome (SS).
Minor salivary glands of 29 patients with primary SS, 28 with secondary SS, 19 with autoimmune diseases without SS, and 17 controls were studied using immunohistochemical techniques. Sections were analyzed with 3 different antibodies reacting with CD25 molecule.
The presence of IL-2R (CD25) was observed in minor salivary gland lymphocytic infiltrate in 26 (89.6%) primary SS, 24 (85.7%) secondary SS, and 16 (84%) autoimmune diseases without SS. CD25 antibody was expressed in epithelial cells in 12 (41%) patients with primary SS and 11 (39%) with secondary SS, but was absent in the group of autoimmune diseases without SS and the control group.
The lymphocytic infiltrate of minor salivary gland expressed IL-2R in patients with primary SS, secondary SS and autoimmune diseases without SS. IL-2R expression in epithelial cells was only present in patients with primary or secondary SS.
研究干燥综合征（SS）患者唾液腺中淋巴细胞和上皮细胞白细胞介素-2受体（IL-2R）的表达情况。
采用免疫组化技术对29例原发性SS患者、28例继发性SS患者、19例无SS的自身免疫性疾病患者及17例对照者的小唾液腺进行研究。用3种与CD25分子反应的不同抗体对切片进行分析。
在26例（89.6%）原发性SS、24例（85.7%）继发性SS及16例（84%）无SS的自身免疫性疾病患者的小唾液腺淋巴细胞浸润中观察到IL-2R（CD25）的存在。12例（41%）原发性SS患者和11例（39%）继发性SS患者的上皮细胞表达CD25抗体，但在无SS的自身免疫性疾病组和对照组中未检测到。
原发性SS、继发性SS及无SS的自身免疫性疾病患者的小唾液腺淋巴细胞浸润均表达IL-2R。上皮细胞中IL-2R的表达仅见于原发性或继发性SS患者。
