Soro A, Ingram M C, Tonolo G, Glorioso N, Fraser R
Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow, UK.
J Hum Hypertens. 1995 Jun;9(6):391-3.
In a large group of patients with untreated hypertension, excretion rates of tetrahydrocorticosterone (THB), allotetrahydrocorticosterone (alloTHB) and tetrahydro-11-dehydrocorticosterone (THA) were all significantly higher than in a group of matched normotensive controls. Using the sum of these metabolites as an index of corticosterone secretion rate suggests that this variable is also higher. The increase was small (all excretion rates remained within the normal range) and corticosterone has low glucocorticoid and mineralocorticoid potency calling the clinical significance of this finding into question. However, it is possible that in combination with mildly deficient 11 beta-hydroxysteroid dehydrogenase activity such increases in corticosterone levels might affect blood pressure.
在一大组未经治疗的高血压患者中，四氢皮质酮（THB）、别四氢皮质酮（alloTHB）和四氢-11-脱氢皮质酮（THA）的排泄率均显著高于一组配对的血压正常对照者。以这些代谢产物的总和作为皮质酮分泌率的指标表明该变量也较高。这种升高幅度较小（所有排泄率仍在正常范围内），且皮质酮的糖皮质激素和盐皮质激素活性较低，这使得这一发现的临床意义受到质疑。然而，有可能在合并轻度缺乏11β-羟类固醇脱氢酶活性的情况下，皮质酮水平的这种升高可能会影响血压。
