与β-淀粉样蛋白肽和阿尔茨海默病相关的治疗方法。 - Suppr

Suppr

超能文献

Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease.

作者信息

Schenk D B, Rydel R E, May P, Little S, Panetta J, Lieberburg I, Sinha S

机构信息

Athena Neurosciences, Inc., South San Francisco, California 94080, USA.

出版信息

J Med Chem. 1995 Oct 13;38(21):4141-54. doi: 10.1021/jm00021a001.

DOI:10.1021/jm00021a001

PMID:7473539

Abstract

摘要

相似文献

Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease.与β-淀粉样蛋白肽和阿尔茨海默病相关的治疗方法。

J Med Chem. 1995 Oct 13;38(21):4141-54. doi: 10.1021/jm00021a001.

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer's Disease.合理设计的肽和肽模拟物作为淀粉样β蛋白（Aβ）聚集的抑制剂：阿尔茨海默病的潜在治疗方法

ACS Comb Sci. 2017 Feb 13;19(2):55-80. doi: 10.1021/acscombsci.6b00116. Epub 2017 Jan 18.

Amyloid forming proteases: therapeutic targets for Alzheimer's disease.淀粉样蛋白形成蛋白酶：阿尔茨海默病的治疗靶点

Curr Pharm Des. 2002;8(28):2521-31. doi: 10.2174/1381612023392658.

Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.通过γ-分泌酶蛋白水解途径抑制淀粉样β肽生成的葑胺磺酰胺抑制剂：治疗阿尔茨海默病的潜在小分子治疗药物。

J Med Chem. 2000 Jun 15;43(12):2297-9. doi: 10.1021/jm990622z.

Secretases as therapeutic targets for Alzheimer's disease.β-分泌酶和γ-分泌酶作为阿尔茨海默病的治疗靶点。

Biochem Biophys Res Commun. 2011 Jan 7;404(1):10-5. doi: 10.1016/j.bbrc.2010.11.132. Epub 2010 Dec 3.

Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.用于阿尔茨海默病淀粉样斑块分子靶向的 6 肽淀粉样β蛋白衍生噬菌体展示文库的设计与评价：与源自随机噬菌体展示文库的两个环状七肽的比较。

Peptides. 2011 Jun;32(6):1232-43. doi: 10.1016/j.peptides.2011.04.026. Epub 2011 May 6.

Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease.反义肽作为阿尔茨海默病β-淀粉样蛋白聚集抑制剂的研发。

Peptides. 2010 Oct;31(10):1866-72. doi: 10.1016/j.peptides.2010.06.033. Epub 2010 Jul 13.

The selective BACE1 inhibitor VIa reduces amyloid-β production in cell and mouse models of Alzheimer's disease.选择性 BACE1 抑制剂 VIa 可减少阿尔茨海默病细胞和小鼠模型中的淀粉样蛋白-β生成。

J Alzheimers Dis. 2013;37(4):823-34. doi: 10.3233/JAD-130836.

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.阿尔茨海默病的淀粉样蛋白假说：治疗之路上的进展与问题

Science. 2002 Jul 19;297(5580):353-6. doi: 10.1126/science.1072994.

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.淀粉样β肽：化学家的视角。在阿尔茨海默病及纤维化中的作用。

Chem Rev. 2012 Oct 10;112(10):5147-92. doi: 10.1021/cr3000994. Epub 2012 Jul 19.

引用本文的文献

A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition.一种新型载脂蛋白 E 拮抗剂能有效阻断载脂蛋白 E 与 N 端淀粉样前体蛋白的相互作用，减少β-淀粉样蛋白相关病理，改善认知。

Biol Psychiatry. 2019 Aug 1;86(3):208-220. doi: 10.1016/j.biopsych.2019.04.026. Epub 2019 May 2.

Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice.地奥司明可降低3xTg-AD小鼠的脑内β-淀粉样蛋白水平、tau蛋白过度磷酸化、神经炎症及认知障碍。

J Neuroimmunol. 2016 Oct 15;299:98-106. doi: 10.1016/j.jneuroim.2016.08.018. Epub 2016 Sep 1.

EVALUATION OF HOW CIGARETTE SMOKE IS A DIRECT RISK FACTOR FOR ALZHEIMER'S DISEASE.评估香烟烟雾如何成为阿尔茨海默病的直接风险因素。

Technol Innov. 2012 Jan 1;14(1):39-48. doi: 10.3727/194982412X13378627621752.

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production.类黄酮介导的早老素-1磷酸化可减少阿尔茨海默病β-淀粉样蛋白的产生。

J Cell Mol Med. 2009 Mar;13(3):574-88. doi: 10.1111/j.1582-4934.2008.00344.x. Epub 2008 Apr 9.

New pathways in drug discovery for Alzheimer's disease.阿尔茨海默病药物研发的新途径。

Curr Neurol Neurosci Rep. 2006 Sep;6(5):372-8. doi: 10.1007/s11910-996-0017-8.

Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process.与胶束结合的人α-突触核蛋白非淀粉样β成分片段的结构与拓扑结构：对聚集过程的影响

Protein Sci. 2006 Jun;15(6):1408-16. doi: 10.1110/ps.052048706.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验