Fournet F, Sannier C, Moriniere M, Porcheron P, Monteny N
Laboratoire d'Entomologie Médicale, ORSTOM, Bondy, France.
J Med Entomol. 1995 Sep;32(5):588-93. doi: 10.1093/jmedent/32.5.588.
Diflubenzuron and OMS 2017 are insect growth regulators that affect larval to adult development in Aedes aegypti (L.) by altering ecdysis. When larvae were exposed to sublethal concentrations, surviving adults express reduced reproductive potential. In mosquitoes, ecdysteroids are important in larval and adult ovarian development. We applied 30% emergence reduction concentrations (EI30) of OMS 2017 and diflubenzuron to 4th-instar Ae. aegypti to determine if changes in ecdysteroid production may explain these physiological effects. Ecdysteroid concentrations were measured in the larvae, pupae, and adults after treatment with both IGRs. After treatment with OMS 2017, the 1st peak of ecdysteroid production in larvae was totally inhibited, but after pupation, ecdysteroid concentrations were the same as in untreated controls. In diflubenzuron-treated larvae, the second peak of production was delayed and the ecdysteroid concentrations of the larvae, pupae, and adults were depressed slightly when compared with untreated controls. The production of ecdysteroids by the ovaries was not altered by sublethal larval treatment with both IGRs. Although OMS 2017 and diflubenzuron belong to the same chemical family, their mode of action apparently is different.
除虫脲和OMS 2017是昆虫生长调节剂，它们通过改变蜕皮过程来影响埃及伊蚊从幼虫到成虫的发育。当幼虫接触亚致死浓度时，存活下来的成虫表现出繁殖潜力下降。在蚊子中，蜕皮甾体在幼虫和成虫卵巢发育中很重要。我们将OMS 2017和除虫脲的30%羽化抑制浓度（EI30）应用于四龄埃及伊蚊，以确定蜕皮甾体产量的变化是否可以解释这些生理效应。在用两种昆虫生长调节剂处理后，测量幼虫、蛹和成虫体内的蜕皮甾体浓度。用OMS 2017处理后，幼虫蜕皮甾体产生的第一个峰值被完全抑制，但化蛹后，蜕皮甾体浓度与未处理的对照相同。在用除虫脲处理的幼虫中，第二个产生峰值延迟，与未处理的对照相比，幼虫、蛹和成虫的蜕皮甾体浓度略有降低。用两种昆虫生长调节剂对幼虫进行亚致死处理后，卵巢中蜕皮甾体的产生没有改变。虽然OMS 2017和除虫脲属于同一化学家族，但它们的作用方式显然不同。
