Ono A, Sekita K, Ohno K, Hirose A, Ogawa Y, Saito M, Naito K, Kaneko T, Furuya T, Matsumoto K
Division of Toxicology, National Institute of Health Sciences, Tokyo, Japan.
J Toxicol Sci. 1995 May;20(2):109-34. doi: 10.2131/jts.20.109.
Toluene is a widely used solvent in industry which is the subject of abuse among the younger generation. A teratogenicity study of toluene by inhalation exposure was carried out in Sprague-Dawley rats and the effects on dams, fetuses and offspring were assessed. Pregnant females were exposed to 600 or 2000 ppm toluene for 6 h/day from day 7 to day 17 of pregnancy. The control group inhaled conditioned clean air under the same exposure conditions. Maternal exposure to 2000 ppm toluene caused significant toxic effects such as body weight suppression of dams and offspring, high fetal mortality and embryonic growth retardation, but no external, internal or skeletal anomalies were observed in the fetuses of any treated group. In addition, there were no differences in the results of pre- and postweaning behavioral tests of the offspring. However, no toxic or teratogenic changes which could be related to toluene exposure were apparent in the 600 ppm group. Further studies are warranted with toluene at higher concentrations applied during the period of organogenesis.
甲苯是一种在工业中广泛使用的溶剂，也是年轻一代滥用的对象。通过吸入暴露对甲苯进行了致畸性研究，在斯普拉格-道利大鼠中进行，并评估了对母鼠、胎儿和后代的影响。怀孕雌性大鼠在妊娠第7天至第17天每天暴露于600或2000 ppm甲苯中6小时。对照组在相同暴露条件下吸入经处理的清洁空气。母体暴露于2000 ppm甲苯会导致显著的毒性作用，如母鼠和后代体重抑制、高胎儿死亡率和胚胎生长迟缓，但在任何处理组的胎儿中均未观察到外部、内部或骨骼异常。此外，后代断奶前和断奶后的行为测试结果没有差异。然而，600 ppm组中没有明显的与甲苯暴露相关的毒性或致畸性变化。有必要在器官发生期应用更高浓度的甲苯进行进一步研究。
