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大T抗原介导的同源重组所需的多瘤病毒复制起点元件。

Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen.

作者信息

Laurent S, Bastin M

机构信息

Department of Biochemistry, University of Sherbrooke, Quebec, Canada.

出版信息

J Virol. 1995 Nov;69(11):7304-8. doi: 10.1128/JVI.69.11.7304-7308.1995.

DOI:10.1128/JVI.69.11.7304-7308.1995
PMID:7474159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189659/
Abstract

We introduced various elements of the polyomavirus origin of DNA replication into the genome of rat cells, and we analyzed their capacity to elicit rearrangements within the integrated sequences when exposed to large T antigen. The cis-acting sequences required for homologous recombination were those that make up a functional replication origin.

摘要

我们将多瘤病毒DNA复制起点的各种元件导入大鼠细胞基因组中，并分析了它们在暴露于大T抗原时引发整合序列内重排的能力。同源重组所需的顺式作用序列是那些构成功能性复制起点的序列。

相似文献

1
Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen.大T抗原介导的同源重组所需的多瘤病毒复制起点元件。
J Virol. 1995 Nov;69(11):7304-8. doi: 10.1128/JVI.69.11.7304-7308.1995.
2
Intrachromosomal recombination mediated by the polyomavirus large T antigen.
Virology. 1995 Jan 10;206(1):227-33. doi: 10.1016/s0042-6822(95)80037-9.
3
Amplification mediated by polyomavirus large T antigen defective in replication.由复制缺陷的多瘤病毒大T抗原介导的扩增。
J Virol. 1993 Aug;67(8):5025-9. doi: 10.1128/JVI.67.8.5025-5029.1993.
4
Deletion of the origin of replication impairs the ability of polyomavirus DNA to transform cells and to form tandem insertions.复制起点的缺失会损害多瘤病毒DNA转化细胞以及形成串联插入的能力。
J Virol. 1984 Mar;49(3):984-7. doi: 10.1128/JVI.49.3.984-987.1984.
5
Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.多瘤病毒核心起始位点中五核苷酸T抗原结合位点两侧的序列有助于确定DNA复制的选择性。
J Virol. 1995 Dec;69(12):7570-8. doi: 10.1128/JVI.69.12.7570-7578.1995.
6
Intrachromosomal recombination mediated by papovavirus large T antigens.乳头瘤病毒大T抗原介导的染色体内重组。
J Virol. 1990 Jun;64(6):2958-66. doi: 10.1128/JVI.64.6.2958-2966.1990.
7
Gene targeting in rat embryo fibroblasts promoted by the polyomavirus large T antigen.多瘤病毒大T抗原促进大鼠胚胎成纤维细胞中的基因靶向。
Nucleic Acids Res. 1996 Jun 1;24(11):1999-2004. doi: 10.1093/nar/24.11.1999.
8
Polyomavirus large T antigen zinc finger is not required for efficient cellular immortalization of primary rat embryo fibroblasts.多瘤病毒大T抗原锌指对于原代大鼠胚胎成纤维细胞的高效细胞永生化并非必需。
Virus Res. 1996 Dec;46(1-2):171-5. doi: 10.1016/s0168-1702(96)01382-2.
9
Site-specific in situ amplification of the integrated polyomavirus genome: a case for a context-specific over-replication model of gene amplification.整合多瘤病毒基因组的位点特异性原位扩增：基因扩增的上下文特异性过度复制模型实例
J Mol Biol. 1997 Aug 8;271(1):76-99. doi: 10.1006/jmbi.1997.1156.
10
Polyomavirus-plasmid recombinants capable of replicating have an enhanced transforming potential.能够复制的多瘤病毒-质粒重组体具有增强的转化潜能。
Mol Cell Biol. 1983 Sep;3(9):1670-4. doi: 10.1128/mcb.3.9.1670-1674.1983.

本文引用的文献

1
High-frequency recombination mediated by polyomavirus large T antigen defective in replication.由复制缺陷的多瘤病毒大T抗原介导的高频重组。
J Virol. 1993 Apr;67(4):1788-95. doi: 10.1128/JVI.67.4.1788-1795.1993.
2
Two novel functions associated with the Rel oncoproteins: DNA replication and cell-specific transcriptional activation.与Rel癌蛋白相关的两种新功能：DNA复制和细胞特异性转录激活。
Oncogene. 1993 Nov;8(11):2889-96.
3
Amplification mediated by polyomavirus large T antigen defective in replication.由复制缺陷的多瘤病毒大T抗原介导的扩增。
J Virol. 1993 Aug;67(8):5025-9. doi: 10.1128/JVI.67.8.5025-5029.1993.
4
Transcription activation mediated by chromosomal inversion in rat cells.大鼠细胞中染色体倒位介导的转录激活。
Oncogene. 1994 Mar;9(3):781-9.
5
Intrachromosomal recombination mediated by the polyomavirus large T antigen.
Virology. 1995 Jan 10;206(1):227-33. doi: 10.1016/s0042-6822(95)80037-9.
6
Spontaneous changes in nucleotide sequence in proviruses of spleen necrosis virus, an avian retrovirus.脾脏坏死病毒（一种禽逆转录病毒）原病毒核苷酸序列的自发变化。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1230-4. doi: 10.1073/pnas.79.4.1230.
7
Amplification and excision of integrated polyoma DNA sequences require a functional origin of replication.整合的多瘤病毒DNA序列的扩增和切除需要一个功能性复制起点。
Cell. 1984 Apr;36(4):943-9. doi: 10.1016/0092-8674(84)90044-8.
8
Non-contiguous segments of the polyoma genome required in cis for DNA replication.多瘤病毒基因组中DNA复制顺式作用所需的非连续片段。
J Mol Biol. 1982 Nov 15;161(4):533-50. doi: 10.1016/0022-2836(82)90406-5.
9
Requirements for excision and amplification of integrated viral DNA molecules in polyoma virus-transformed cells.多瘤病毒转化细胞中整合病毒DNA分子的切除和扩增要求。
J Virol. 1982 Aug;43(2):617-28. doi: 10.1128/JVI.43.2.617-628.1982.
10
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors.克隆至M13载体的DNA片段的寡核苷酸定向诱变
Methods Enzymol. 1983;100:468-500. doi: 10.1016/0076-6879(83)00074-9.