Nygård O, Vollset S E, Refsum H, Stensvold I, Tverdal A, Nordrehaug J E, Ueland M, Kvåle G
Section for Medical Informatics and Statistics, University of Bergen, Norway.
JAMA. 1995 Nov 15;274(19):1526-33. doi: 10.1001/jama.1995.03530190040032.
To estimate the relations between established cardiovascular risk factors and total homocysteine (tHcy) in plasma.
Health examination survey by the Norwegian Health Screening Service in 1992 and 1993.
General community, Hordaland County of Western Norway.
A total of 7591 men and 8585 women, 40 to 67 years of age, with no history of hypertension, diabetes, coronary heart disease, or cerebrovascular disease were included.
Plasma tHcy level.
The level of plasma tHcy was higher in men than in women and increased with age. In subjects 40 to 42 years old, geometric means were 10.8 mumol/L for 5918 men and 9.1 mumol/L for 6348 women. At age 65 to 67 years, the corresponding tHcy values were 12.3 mumol/L (1386 men) and 11.0 mumol/L (1932 women). Plasma tHcy level increased markedly with the daily number of cigarettes smoked in all age groups. Its relation to smoking was particularly strong in women. The combined effect of age, sex, and smoking was striking. Heavy-smoking men aged 65 to 67 years had a mean tHcy level 4.8 mumol/L higher than never-smoking women aged 40 to 42 years. Plasma tHcy level also was positively related to total cholesterol level, blood pressure, and heart rate and inversely related to physical activity. The relations were not substantially changed by multivariate adjustment, including intake of vitamin supplements, fruits, and vegetables.
Elevated plasma tHcy level was associated with major components of the cardiovascular risk profile, ie, male sex, old age, smoking, high blood pressure, elevated cholesterol level, and lack of exercise. These findings should influence future studies on the etiology and pathogenesis of cardiovascular disease.
评估已确定的心血管危险因素与血浆总同型半胱氨酸（tHcy）之间的关系。
1992年和1993年挪威健康筛查服务中心进行的健康检查调查。
挪威西部霍达兰郡的普通社区。
纳入了7591名男性和8585名女性，年龄在40至67岁之间，无高血压、糖尿病、冠心病或脑血管疾病史。
血浆tHcy水平。
男性血浆tHcy水平高于女性，且随年龄增长而升高。在40至42岁的受试者中，5918名男性的几何平均值为10.8μmol/L，6348名女性为9.1μmol/L。在65至67岁时，相应的tHcy值分别为12.3μmol/L（1386名男性）和11.0μmol/L（1932名女性）。在所有年龄组中，血浆tHcy水平均随每日吸烟量的增加而显著升高。其与吸烟的关系在女性中尤为明显。年龄、性别和吸烟因素的综合作用显著。65至67岁的重度吸烟男性的平均tHcy水平比40至42岁从不吸烟的女性高4.8μmol/L。血浆tHcy水平还与总胆固醇水平、血压和心率呈正相关，与体力活动呈负相关。多变量调整（包括维生素补充剂、水果和蔬菜的摄入量）后，这些关系没有实质性变化。
血浆tHcy水平升高与心血管风险概况的主要组成部分相关，即男性、老年、吸烟、高血压、胆固醇水平升高和缺乏运动。这些发现应会影响未来关于心血管疾病病因和发病机制的研究。
