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基于内源性卟啉激光诱导荧光的胃部疾病光谱诊断

[Spectroscopic diagnosis of stomach diseases based on laser-induced fluorescence of endogenous porphyrins].

作者信息

Kuzin M I, Kuzin N M, Shkrob O S, Kharnas S S, Loshchenov V B, Zavodnov V Ia, Merzliakov A E

出版信息

Khirurgiia (Mosk). 1995(5):35-7.

PMID:7474702
Abstract

For higher efficacy of early gastric carcinoma diagnosis by endoscopy, the authors suggest a method of autofluorescent diagnostics. It is d=based on the property of endogenous porphyrins contained in the tumor to emit light under the effect of laser. The suggested method was used in examination of 54 patients. The experimental group was composed of 35 patients with gastric carcinoma, the control group was formed of 21 patients with benign diseases gastric ulcer, polyps, chronic gastritis). The sensitivity of the method was 94%, th specificity 90.5%. It is shown that the method of autofluorescent diagnostics may be applied in cases which are difficult for diagnosis.

摘要

为了提高早期胃癌内镜诊断的效率,作者提出了一种自体荧光诊断方法。该方法基于肿瘤内所含内源性卟啉在激光作用下发光的特性。所提出的方法用于54例患者的检查。实验组由35例胃癌患者组成,对照组由21例患有良性疾病(胃溃疡、息肉、慢性胃炎)的患者组成。该方法的敏感性为94%,特异性为90.5%。结果表明,自体荧光诊断方法可应用于诊断困难的病例。

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