Häntzschel H, Otto W, Reinelt D
Arch Geschwulstforsch. 1978;48(5):391-5.
Activity and results of therapy of joint diseases can be evaluated by means of cytological examinations of the synovia which is at the same time a prerequisite for differential diagnosis using the puncture fluid. Our cytological examinations of more than 700 puncture fluids stemming from different joint diseases were carried out immediately after the puncture on the fresh material, in order to prevent misinterpretation. This may occur through flaking out in stored material, which results in decrease in the cell count and a non-representative differential cell picture in the supernatant, as well as through degeneration of cells. In two thirds of our patients the local process activity, measured in terms of the cytological phase of activity, became evident in the total clinical activity. The synovia analysis furthermore permits objective assessment of the result of intra-articular injection treatment. Intractable activity, substantiated through synovia examination indicates synovectomy.
关节疾病的活动情况及治疗结果可通过滑膜的细胞学检查来评估，而滑膜的细胞学检查同时也是使用穿刺液进行鉴别诊断的前提条件。我们对700多份源自不同关节疾病的穿刺液进行了细胞学检查，穿刺后立即对新鲜样本进行检查，以防止出现误判。误判可能是由于储存样本中的细胞成片脱落，导致细胞计数减少以及上清液中细胞分类图像不具代表性，也可能是由于细胞变性。在我们三分之二的患者中，根据细胞学活动阶段衡量的局部病变活动在总体临床活动中表现明显。此外，滑膜分析还能对关节内注射治疗的结果进行客观评估。通过滑膜检查证实的顽固性活动表明需要进行滑膜切除术。
