Hietala J, Syvälahti E, Vuorio K, Räkköläinen V, Bergman J, Haaparanta M, Solin O, Kuoppamäki M, Kirvelä O, Ruotsalainen U
Department of Pharmacology, University of Turku, Finland.
Lancet. 1995 Oct 28;346(8983):1130-1. doi: 10.1016/s0140-6736(95)91801-9.
Presynaptic dopamine function (6-[18F]-fluorodopa uptake) in the brains of seven neuroleptic-naive first-admission schizophrenic patients and eight healthy controls was studied with positron emission tomography. The fluorodopa influx constant (Ki) in putamen was higher in the patients than in controls (average mean: 0.0149 vs 0.0129, p = 0.034). The changes in caudate were smaller but significantly lateralised to the left caudate. There was one catatonic schizophrenic patient in our sample. This patient had lower striatal Ki than any control. Alterations in striatal presynaptic dopamine function may constitute a part of disrupted neural circuits that predispose to schizophrenic psychosis.
利用正电子发射断层扫描技术，对7名未服用过抗精神病药物的首次入院精神分裂症患者及8名健康对照者大脑中的突触前多巴胺功能（6-[18F]-氟多巴摄取）进行了研究。患者壳核中的氟多巴流入常数（Ki）高于对照组（平均均值：0.0149对0.0129，p = 0.034）。尾状核的变化较小，但显著偏向左侧尾状核。我们的样本中有1名紧张型精神分裂症患者。该患者的纹状体Ki低于任何一名对照者。纹状体突触前多巴胺功能的改变可能是导致精神分裂症性精神病的神经回路破坏的一部分。
