Ortiz de Urbina D, Santos M, Garcia-Berrocal I, Bustos J C, Samblas J, Gutierrez-Diaz J A, Delgado J M, Donckaster G, Calvo F A
Department of Radiation Oncology, San Francisco de Asis Hospital, Madrid, Spain.
Neurol Res. 1995 Aug;17(4):289-94. doi: 10.1080/01616412.1995.11740329.
Intraoperative radiation therapy (IORT) with high energy electron beams is a treatment modality that has been included in multimodal programs in oncology to improve local tumor control. From August 1991 to December 1993, 17 patients with primary (8) or recurrent (9) high grade malignant gliomas, anaplastic astrocytoma (4), anaplastic oligodendroglioma (6) and glioblastoma multiforme (7), underwent surgical resection and a single dose of 10-20 Gy intraoperative radiation therapy was delivered in tumor bed. Fourteen patients received either pre-operative (8) or post-operative (6) external beam radiation therapy. Primary gliomas: 18-months actuarial survival rate has been 56% (range: 1-21+ months) and the median survival time has not yet been achieved. Four patients developed tumor progression (median time to tumor progression: 9 months). Recurrent gliomas: 18-months actuarial survival rate and median survival time has been 47% and 13 months (range: 6-32+ months) respectively. The median time to tumor progression was 11 months. No IORT related mortality has been observed. IORT is an attractive, tolerable and feasible treatment modality as antitumoral intensification procedure in high grade malignant gliomas.
术中高能电子束放射治疗（IORT）是一种已被纳入肿瘤多模式治疗方案以改善局部肿瘤控制的治疗方式。1991年8月至1993年12月，17例原发性（8例）或复发性（9例）高级别恶性胶质瘤患者，包括间变性星形细胞瘤（4例）、间变性少突胶质细胞瘤（6例）和多形性胶质母细胞瘤（7例），接受了手术切除，并在肿瘤床给予单次剂量10 - 20 Gy的术中放射治疗。14例患者接受了术前（8例）或术后（6例）外照射放疗。原发性胶质瘤：18个月精算生存率为56%（范围：1 - 21 +个月），中位生存时间尚未达到。4例患者出现肿瘤进展（肿瘤进展的中位时间：9个月）。复发性胶质瘤：18个月精算生存率和中位生存时间分别为47%和13个月（范围：6 - 32 +个月）。肿瘤进展的中位时间为11个月。未观察到与IORT相关的死亡。作为高级别恶性胶质瘤的抗肿瘤强化治疗手段，IORT是一种有吸引力、可耐受且可行的治疗方式。
