Reichel H
Department of Internal Medicine, University of Heidelberg, Germany.
Nephrol Dial Transplant. 1995;10 Suppl 4:33-6; discussion p. 37-43. doi: 10.1093/ndt/10.supp4.33.
In summary, the biological effects of 1,25(OH)2D3 on the parathyroid glands probably persist for several days, although the plasma half-life of 1,25(OH)2D3 is only several hours. This is a theoretical argument for 1,25(OH)2D3 pulse therapy, and suggests that spacing of pulses could be chosen even wider (one-two pulses per week) than was previously thought (three pulses per week). Under the conditions of experiment in subtotally nephrectomized rats, the biological effect on the parathyroid glands was correlated best with the achieved peak 1,25(OH)2D3 serum concentration. This would be another argument for pulse therapy with active vitamin D metabolites.
总之，1,25(OH)₂D₃ 对甲状旁腺的生物学效应可能会持续数天，尽管 1,25(OH)₂D₃ 的血浆半衰期仅为几个小时。这是支持 1,25(OH)₂D₃ 脉冲疗法的一个理论依据，表明脉冲间隔可以比之前认为的（每周三次脉冲）选择得更宽（每周一至两次脉冲）。在次全肾切除大鼠的实验条件下，对甲状旁腺的生物学效应与所达到的 1,25(OH)₂D₃ 血清峰值浓度相关性最佳。这将是支持活性维生素 D 代谢物脉冲疗法的另一个依据。
