在伴有神经原纤维缠结的亚急性硬化性全脑炎病例中，少突胶质细胞内有大量神经胶质原纤维缠结。
Numerous glial fibrillary tangles in oligodendroglia in cases of subacute sclerosing panencephalitis with neurofibrillary tangles.
作者信息
Ikeda K, Akiyama H, Kondo H, Arai T, Arai N, Yagishita S
机构信息
Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.
出版信息
Neurosci Lett. 1995 Jul 14;194(1-2):133-5. doi: 10.1016/0304-3940(95)11713-7.
Both neurons and oligodendroglia are preferentially infected in subacute sclerosing panencephalitis (SSPE). Massive argyrophilic and tau-positive glial fibrillary tangles (GFT) were found in oligodendroglia in two autopsy cases of SSPE with neurofibrillary tangles (NFT). GFT shared common phosphorylated tau-epitopes with NFT, but were negative for ubiquitin. Electron microscopically, GFT consisted of compact bundles of irregularly woven tubules. Thus, GFT in SSPE differed from NFT showing regular constriction of tubules and from GFT in some other cytoskeletal disorders in which GFT reportedly consisted of straight tubules.
在亚急性硬化性全脑炎（SSPE）中，神经元和少突胶质细胞均易受感染。在两例伴有神经原纤维缠结（NFT）的SSPE尸检病例中，在少突胶质细胞中发现了大量嗜银性和tau阳性的胶质纤维缠结（GFT）。GFT与NFT具有共同的磷酸化tau表位，但对泛素呈阴性。电子显微镜下，GFT由紧密排列的不规则编织小管束组成。因此，SSPE中的GFT不同于显示小管规则收缩的NFT，也不同于据报道由直小管组成的其他一些细胞骨架疾病中的GFT。
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