Huang W, Zhai Q Z, Sjöquist M
Department of Physiology and Medical Biophysics, Uppsala University, Sweden.
Neurosci Lett. 1995 Jul 28;195(1):33-6. doi: 10.1016/0304-3940(95)11773-p.
We have previously shown that oxytocin (OT) is a major humoral mediator in postnephrectomy natriuresis. As immunoassayable OT has been demonstrated in the spinal cord, the aim of this investigation was to determine whether OT receptors in the spinal cord are also involved in this natriuresis. The experiments were performed on anesthetized male rats. Before acute unilateral nephrectomy, an oxytocin-receptor antagonist was injected intrathecally in the thoracolumbar region in rats. Postnephrectomy natriuresis was attenuated by this injection but not by intrathecal injection of artificial cerebrospinal fluid. Our results suggest that OT receptors within the spinal cord may influence the autonomic nervous regulation of renal function. In an additional experiment, intravenously infused hexamethonium did not prevent the adaptive natriuresis in the remaining kidney. We conclude that OT receptors in the spinal cord are involved in the postnephrectomy natriuresis, possibly as a component in the afferent signal pathway.
我们之前已经表明，催产素（OT）是肾切除术后利钠的主要体液介质。由于在脊髓中已证实存在可免疫检测的OT，本研究的目的是确定脊髓中的OT受体是否也参与这种利钠过程。实验在麻醉的雄性大鼠身上进行。在急性单侧肾切除术前，将催产素受体拮抗剂鞘内注射到大鼠的胸腰段区域。这种注射减弱了肾切除术后的利钠作用，但鞘内注射人工脑脊液则没有这种效果。我们的结果表明，脊髓内的OT受体可能影响肾功能的自主神经调节。在另一项实验中，静脉注射六甲铵并不能阻止剩余肾脏的适应性利钠作用。我们得出结论，脊髓中的OT受体参与了肾切除术后的利钠过程，可能是传入信号通路的一个组成部分。
