帕金森病脑组织中MxA阳性路易小体的进一步观察

Further observations on MxA-positive Lewy bodies in Parkinson's disease brain tissues.

作者信息

Yamada T

机构信息

Department of Neurology, Chiba University, Japan.

出版信息

Neurosci Lett. 1995 Jul 28;195(1):41-4. doi: 10.1016/0304-3940(95)11777-t.

DOI:10.1016/0304-3940(95)11777-t

PMID:7478250

Abstract

MxA protein, one of the GTPases, is induced in the cytoplasm by interferons and confers a high degree of resistance to some viruses. We recently reported that in cases of Parkinson's disease (PD), Lewy bodies (LBs) in the substantia nigra (SN) were positive for MxA. This study aimed to provide more detailed data on MxA-positive structures in the SN in PD brain tissues. Swellings of neuronal processes, as well as LBs, were positive for MxA. Immuno-electron microscopy revealed that reaction products corresponding to MxA proteins localized in self-aggregations similar to those reported for Mx1 protein in mouse tissues. These results show that MxA may play a role in the formation of LBs and swellings of neuronal processes.

摘要

MxA蛋白是一种GTP酶，由干扰素在细胞质中诱导产生，对某些病毒具有高度抗性。我们最近报道，在帕金森病（PD）患者中，黑质（SN）中的路易小体（LBs）呈MxA阳性。本研究旨在提供关于PD脑组织中SN中MxA阳性结构的更详细数据。神经元突起的肿胀以及LBs均呈MxA阳性。免疫电子显微镜显示，与MxA蛋白对应的反应产物定位于类似于小鼠组织中Mx1蛋白报道的自聚集物中。这些结果表明，MxA可能在LBs的形成和神经元突起的肿胀中起作用。