血清离子钙升高对生长抑素抑制人体葡萄糖诱导胰岛素释放的影响。

The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans.

作者信息

Wajchenberg B L, Cesar F P, Leme C E, Silva H B, Lerario A C, Coy D H, Schally A V

出版信息

Clin Endocrinol (Oxf). 1978 Dec;9(6):515-21. doi: 10.1111/j.1365-2265.1978.tb01509.x.

DOI:10.1111/j.1365-2265.1978.tb01509.x

Abstract

The effect of somatostatin on the insulin response to an acute intravenous glucose load was studied in five normal subjects before and after induction hypercalcaemia. In the normocalcaemic state, the insulin response to glucose was depressed by somatostatin. In the hypercalcaemic state, insulin responses to glucose in the presence of somatostatin, were partially restored and appeared to be related to the level of increment of serum ionized calcium. It is concluded that, in the human being, hypercalcaemia and somatostatin have opposite actions on glucose-stimulated insulin secretion.

摘要

在五名正常受试者中，研究了高钙血症诱导前后生长抑素对急性静脉注射葡萄糖负荷时胰岛素反应的影响。在血钙正常状态下，生长抑素抑制了对葡萄糖的胰岛素反应。在高钙血症状态下，生长抑素存在时对葡萄糖的胰岛素反应部分恢复，且似乎与血清离子钙的升高水平有关。得出的结论是，在人类中，高钙血症和生长抑素对葡萄糖刺激的胰岛素分泌具有相反的作用。