Gnüchtel U, Wallrabe D, Nitschkoff S
Cor Vasa. 1978;20(6):409-16.
In continuation of their studies concerning changes in the reactivity of vascular segments under isolated perfusion in vivo with simultaneous experimental disturbance of transmembranous distribution of electrolytes, the authors investigated in ten rabbits the effect of noradrenaline in the ear with isolated circulation. After perfusion of an ouabain solution (total concentration: 0.4 X 10(-5) M), in dependence on the duration of the effect of glycoside the vasoconstrictor response to 0.1 and 0.5 micrograms noradrenaline was significantly strengthened, up to 40% of the initial value. After washing-out of the vascular segment under isolated perfusion with Krebs-Henseleit solution, and ensuing restoration of normal cation relationships, the vascular reactivity returned to its initial level. Potential analogous mechanisms of the etiology and pathogenesis of essential hypertension are discussed.
在继续进行关于体内孤立灌注时血管段反应性变化的研究（同时对电解质跨膜分布进行实验性干扰）中，作者在十只兔子身上研究了去甲肾上腺素对孤立循环耳部的影响。在用哇巴因溶液（总浓度：0.4×10⁻⁵M）灌注后，根据糖苷作用的持续时间，对0.1和0.5微克去甲肾上腺素的血管收缩反应显著增强，达到初始值的40%。在用克雷布斯 - 亨泽莱特溶液对孤立灌注的血管段进行冲洗，并随后恢复正常阳离子关系后，血管反应性恢复到初始水平。文中讨论了原发性高血压病因和发病机制的潜在类似机制。
