Fehmann H C, Hering B J, Wolf M J, Brandhorst H, Brandhorst D, Bretzel R G, Federlin K, Göke B
Department of Medicine, Philipps-University of Marburg, Germany.
Pancreas. 1995 Aug;11(2):196-200. doi: 10.1097/00006676-199508000-00014.
Glucagon-like peptide-I (GLP-I) is a potent incretin hormone that is now considered as a new therapeutic tool in the treatment of diabetes mellitus. In this study we characterized the effects of GLP-I on peptide hormone release from isolated human pancreatic islets. GLP-I stimulated insulin release in the presence of 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%; 10 mM glucose + 10 nM GLP-I, 222%) but had only a weak insulinotropic effect (128%) at 2.8 mM glucose. Glucagon release was inhibited by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 72%) and by 10 nM GLP-I at 2.8 mM glucose (67%). Somatostatin secretion was increased by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%). GLP-I stimulated somatostatin release in the presence of 2.8 mM glucose (172%). Pancreatic polypeptide (PP) secretion was enhanced by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 236%). GLP-I induced PP release only in the presence of 2.8 mM glucose (184%).
胰高血糖素样肽 -1（GLP -1）是一种强效的肠促胰岛素激素，目前被视为治疗糖尿病的一种新的治疗工具。在本研究中，我们描述了GLP -1对分离的人胰岛中肽类激素释放的影响。GLP -1在10 mM葡萄糖存在下刺激胰岛素释放（2.8 mM葡萄糖时为100%；10 mM葡萄糖时为166%；10 mM葡萄糖 + 10 nM GLP -1时为222%），但在2.8 mM葡萄糖时仅具有微弱的促胰岛素作用（128%）。胰高血糖素释放在10 mM葡萄糖时受到抑制（2.8 mM葡萄糖时为100%；10 mM葡萄糖时为72%），在2.8 mM葡萄糖时受到10 nM GLP -1的抑制（67%）。生长抑素分泌在10 mM葡萄糖时增加（2.8 mM葡萄糖时为100%；10 mM葡萄糖时为166%）。GLP -1在2.8 mM葡萄糖存在下刺激生长抑素释放（172%）。胰多肽（PP）分泌在10 mM葡萄糖时增强（2.8 mM葡萄糖时为100%；10 mM葡萄糖时为236%）。GLP -1仅在2.8 mM葡萄糖存在时诱导PP释放（184%）。
