Coscelli C, Alpi O, Butturini U
Chronobiologia. 1978 Oct-Dec;5(4):387-90.
The response of glucose, FFA and immunoreactive insulin to intravenous glucose and glucagon was examined in 6 apparently healthy subjects aged 67-77 years at 08(00) and 18(00) with a 3 day interval. The subjects, fasted 12 h before each test, received 0.5 g/kg of glucose i.v. and, 40 min after glucose, 1 mg glucagon i.v. The results confirmed, also in aged subjects, an impaired glucose tolerance in the afternoon test, as previously reported in the adult subject. The insulin response was delayed in the afternoon test, but the total incremental area was not significantly reduced. There was not a clearcut difference in the pattern of FFA response. The results could be a further confirmation of the central role of insulin response as a cause of impaired glucose tolerance in the afternoon also in subjects aged over 65 years.
在6名年龄在67 - 77岁的明显健康受试者中，于08(00)和18(00)时间点，间隔3天对静脉注射葡萄糖和胰高血糖素后葡萄糖、游离脂肪酸（FFA）及免疫反应性胰岛素的反应进行了检测。每次检测前受试者禁食12小时，静脉注射0.5 g/kg葡萄糖，在注射葡萄糖40分钟后，静脉注射1 mg胰高血糖素。结果证实，与之前在成年受试者中报道的一样，在老年受试者中，下午的检测也存在糖耐量受损。下午检测时胰岛素反应延迟，但总增量面积未显著降低。游离脂肪酸反应模式没有明显差异。这些结果可能进一步证实了胰岛素反应在65岁以上受试者下午糖耐量受损原因中所起的核心作用。
