Miller R D, Hogg J, Ozaki J H, Gell D, Jackson S P, Riblet R
Department of Biology, University of New Mexico, Albuquerque 87131, USA.
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10792-5. doi: 10.1073/pnas.92.23.10792.
The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.
最近有人提出，编码依赖DNA的蛋白激酶催化亚基（DNA-PKcs）的基因是小鼠严重联合免疫缺陷（scid）位点的候选基因。我们利用人DNA-PKcs的部分cDNA克隆，通过一个大型种间回交群体对小鼠同源基因进行定位。我们发现，小鼠的DNA-PKcs基因与scid没有重组，这与scid是小鼠DNA-PKcs基因突变的假说一致。
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