Galtier N, Gouy M
Centre National de la Recherche Scientifique, Université Claude Bernard Lyon, Villeurbanne, France.
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11317-21. doi: 10.1073/pnas.92.24.11317.
A new method for computing evolutionary distances between DNA sequences is proposed. Contrasting with classical methods, the underlying model does not assume that sequence base compositions (A, C, G, and T contents) are at equilibrium, thus allowing unequal base compositions among compared sequences. This makes the method more efficient than the usual ones in recovering phylogenetic trees from sequence data when base composition is heterogeneous within the data set, as we show by using both simulated and empirical data. When applied to small-subunit ribosomal RNA sequences from several prokaryotic or eukaryotic organisms, this method provides evidence for an early divergence of the microsporidian Vairimorpha necatrix in the eukaryotic lineage.
提出了一种计算DNA序列进化距离的新方法。与传统方法不同，该基础模型不假定序列碱基组成（A、C、G和T含量）处于平衡状态，因此允许比较序列之间的碱基组成不相等。正如我们使用模拟数据和实证数据所表明的，当数据集中碱基组成存在异质性时，该方法在从序列数据中恢复系统发育树方面比常用方法更有效。当应用于来自几种原核生物或真核生物的小亚基核糖体RNA序列时，该方法为微孢子虫奈氏变形孢在真核生物谱系中的早期分化提供了证据。
