Amir S M, Uchimura H, Ingbar S H
Endocr Res Commun. 1978;5(3):239-47. doi: 10.1080/07435807809083757.
Previous studies have shown that crude preparations of human chorionic gonadotropin bind to bovine thyroid membranes, displace 125I-labeled bovine thyrotropin therefrom, and are weak agonists therein with respect to the activation of adenylate cyclase. The present studies reveal that concentrations of chorionic gonadotropin sufficient to elicit a maximal agonistic response of adenylate cyclase are strongly antagonistic to the stimulatory action of bovine thyrotropin in the thyroid membrane system. This effect is reminiscent of the inhibitory effects of crude human chorionic gonadotropin on other extragonadal tissues in vitro, and, like them, appears to be mediated by some factor(s) other than human chorionic gonadotropin itself, since highly purified human chorionic gonadotropin was without effect.
以往的研究表明，人绒毛膜促性腺激素的粗制品能与牛甲状腺膜结合，从该膜上置换出125I标记的牛促甲状腺激素，并且在激活腺苷酸环化酶方面是弱激动剂。目前的研究表明，足以引发腺苷酸环化酶最大激动反应的绒毛膜促性腺激素浓度，在甲状腺膜系统中对牛促甲状腺激素的刺激作用具有强烈的拮抗作用。这种效应让人想起粗制人绒毛膜促性腺激素在体外对其他性腺外组织的抑制作用，而且与它们一样，似乎是由人绒毛膜促性腺激素本身以外的某些因素介导的，因为高度纯化的人绒毛膜促性腺激素没有这种作用。
