Buckley P, O'Callaghan E, Mulvany F, Larkin C, Stack J P, Redmond O, Ennis J T, Thompson P, Waddington J L
Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, OH 44106, USA.
Psychiatry Res. 1995 Aug 8;61(2):95-102. doi: 10.1016/0925-4927(95)02591-k.
Transverse, or spin-spin, relaxation times (T2) from magnetic resonance images of basal ganglia structures were compared between control subjects and patients with schizophrenia, who were subdivided on the basis of the presence or absence of tardive dyskinesia. As a group, schizophrenic patients showed evidence of somewhat more prolonged T2 relaxation times in the right putamen and globus pallidus than did control subjects; there were no significant correlations between hemispheric T2 values and corresponding volumes of the lateral ventricles. Overall, there was little difference in T2 values between patients with and without tardive dyskinesia. These data extend the range of evidence for basal ganglia dysfunction in schizophrenia, but they do not support earlier reports of prominent T2 changes associated with tardive dyskinesia.
比较了对照组与精神分裂症患者基底节结构磁共振图像的横向或自旋-自旋弛豫时间(T2),精神分裂症患者根据是否存在迟发性运动障碍进行了细分。作为一个群体,精神分裂症患者右侧壳核和苍白球的T2弛豫时间比对照组略有延长;半球T2值与侧脑室相应体积之间无显著相关性。总体而言,有和没有迟发性运动障碍的患者之间T2值差异不大。这些数据扩展了精神分裂症基底节功能障碍的证据范围,但不支持早期关于与迟发性运动障碍相关的显著T2变化的报道。