排除精神分裂症与多巴胺D2受体（DRD2）基因及11号染色体q易位位点的连锁关系。

Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites.

作者信息

Kalsi G, Mankoo B S, Curtis D, Brynjolfsson J, Read T, Sharma T, Murphy P, Petursson H, Gurling H M

机构信息

Academic Department of Psychiatry, University College, London.

出版信息

Psychol Med. 1995 May;25(3):531-7. doi: 10.1017/s0033291700033456.

DOI:10.1017/s0033291700033456

PMID:7480434

Abstract

There have been previous reports of a 1q43;11q21 translocation cosegregating with schizophrenia and a 9p22;11q22.3 translocation cosegregating with manic depression. In addition, the genes for the dopamine D2 receptor and for tyrosinase both map to chromosome 11q. Three 11q DNA markers were used to investigate 23 pedigrees containing multiple cases of schizophrenia. Strongly negative lod scores were obtained, providing evidence against linkage over a 70 cM region which included both translocation sites and both candidate genes.

摘要

此前已有报道称，1q43;11q21易位与精神分裂症共分离，9p22;11q22.3易位与躁郁症共分离。此外，多巴胺D2受体基因和酪氨酸酶基因均定位于11号染色体q臂。使用三个11q DNA标记对23个包含多例精神分裂症病例的家系进行了研究。获得了强烈的负对数优势分数，为在一个包括两个易位位点和两个候选基因的70厘摩区域内不存在连锁提供了证据。