Levine D, Gosink B B, Johnson L A
Department of Radiology, Beth Israel Hospital, Boston, MA 02215, USA.
Radiology. 1995 Dec;197(3):603-8. doi: 10.1148/radiology.197.3.7480726.
To evaluate the effect over time of hormone replacement on endometrial thickness in asymptomatic postmenopausal women.
Endometrial thickness was measured on 644 sonograms of 120 postmenopausal volunteers receiving no hormones or one of three hormone regimens. Each subject underwent ultrasound (US) two to nine times. In addition, eight women using sequential hormones underwent US seven to 20 times over 2 months. The greatest endometrial thickness and change in endometrial thickness over time were evaluated.
Endometrial thickness was statistically significantly greater in women using sequential hormones (8 mm) compared with that in control subjects (5 mm). Change in endometrial thickness (> 3-mm difference) was seen in 23 of 40 women using sequential hormones compared with six of 61 controls. Women using sequential hormones demonstrated maximum endometrial thickness on days 13-23 of the cycle.
Women using sequential hormones show greater endometrial thickness than that in controls and show the most variation in measurements. They should undergo US either early or late in the hormone cycle to evaluate the endometrium at its thinnest.
评估激素替代疗法对无症状绝经后女性子宫内膜厚度随时间的影响。
对120名未接受激素治疗或接受三种激素治疗方案之一的绝经后志愿者的644份超声图像进行子宫内膜厚度测量。每位受试者接受了2至9次超声检查。此外，8名使用序贯激素的女性在2个月内接受了7至20次超声检查。评估了最大子宫内膜厚度以及子宫内膜厚度随时间的变化。
使用序贯激素的女性子宫内膜厚度（8毫米）在统计学上显著高于对照组（5毫米）。40名使用序贯激素的女性中有23名出现子宫内膜厚度变化（差异>3毫米），而61名对照组中只有6名出现这种情况。使用序贯激素的女性在月经周期的第13至23天出现最大子宫内膜厚度。
使用序贯激素的女性子宫内膜厚度大于对照组，且测量值变化最大。她们应在激素周期的早期或晚期接受超声检查，以评估最薄时的子宫内膜情况。
