Zheng Q
Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502, USA.
Risk Anal. 1995 Aug;15(4):495-502. doi: 10.1111/j.1539-6924.1995.tb00342.x.
This paper proposes extending the MVK carcinogenesis model by adopting the Erlang distribution for the life length of the intermediate cells. The investigation concentrates on the survival function and the mean value functions. The approach is basically numerical, making use of the Mathematica software system. The paper also provides a closed form expression for the survival function for a variation of the original MVK model, where all the model parameters are piecewise constants.
本文提出通过采用中间细胞寿命的埃尔朗分布来扩展MVK致癌模型。研究集中在生存函数和均值函数上。该方法基本上是数值方法,利用Mathematica软件系统。本文还为原始MVK模型的一个变体的生存函数提供了一个封闭形式的表达式,其中所有模型参数都是分段常数。