Hansen B L, Andersen K
Department of Internal Medicine C, University Hospital of Odense, Denmark, Sweden.
Scand J Rheumatol. 1995;24(4):248-50. doi: 10.3109/03009749509100883.
Fungal arthritis (FA) due to a candida infection was reviewed in English literature and described in 45 cases. The increasing use of potent antibiotics, immunosuppressives, and especially the use of artificial joints, predisposed to the infection. Weightbearing joints, particularly the knees, were most frequently affected. Symptoms were described as a warm, tender and swollen joint, and the duration of symptoms prediagnosis was described as being up to 4 years. Amphotericin B was the treatment drug of choice, and in cases of no response, supplemented with either flucytosine or ketoconazole. Local FA healed in all cases. FA in an artificial joint resulted in all cases in removal of the prostheses. Mortality in systemic fungal infections including FA was 50%.
英文文献综述了由念珠菌感染引起的真菌性关节炎（FA），共描述了45例病例。强效抗生素、免疫抑制剂的使用增加，尤其是人工关节的使用，易引发感染。负重关节，尤其是膝关节，最常受累。症状表现为关节发热、压痛和肿胀，症状出现至确诊的持续时间长达4年。两性霉素B是首选治疗药物，若无效则加用氟胞嘧啶或酮康唑。所有局部FA病例均治愈。人工关节感染FA的所有病例均进行了假体移除。包括FA在内的全身性真菌感染的死亡率为50%。
