Ziparo E, Lemay A, Marchesi V T
J Cell Sci. 1978 Dec;34:91-101. doi: 10.1242/jcs.34.1.91.
Spectrin molecules are distributed uniformly throughout the submembranous regions of intact human erythrocytes. Spectrin does not appear to extend into the red blood cell cytoplasm to any significant extent. Thus, it does not form a recognizable internal scaffolding nor does it seem to connect distant segments of the cell membrane. Spectrin retains its submembranous location in the spiny processes of echinocytes produced by ATP depletion. Thus, these processes do not seem to form by a simple extrusion mechanism powered by contraction of the spectrin network. Spectrin seems to be important for the stability of the lipid bilayer of the red cell membrane, and it probably also plays a role in regulating red cell shape. How it performs either function is still unknown.
血影蛋白分子均匀分布于完整人类红细胞的膜下区域。血影蛋白似乎并未显著延伸至红细胞胞质内。因此，它既不形成可识别的内部支架，也似乎不连接细胞膜的远距离片段。在因ATP耗竭产生的棘状红细胞的棘突中，血影蛋白仍保留在膜下位置。因此，这些棘突似乎并非由血影蛋白网络收缩驱动的简单挤压机制形成。血影蛋白似乎对红细胞膜脂质双层的稳定性很重要，并且它可能在调节红细胞形状方面也发挥作用。它如何执行这两种功能仍不清楚。
