Mishchuk V H, Neĭko Ie M
Lik Sprava. 1995 Jan-Feb(1-2):59-62.
The blood serum content of secretin, vasointestinal peptide (VIP), glucagon and insulin was studied in 112 patients with chronic gastritis presenting with secretory deficiency, and 12 essentially healthy subjects. It was established that in surface, fundal and pangastritis the levels of secretin and VIP did not differ from the values in healthy individuals. The secretin concentration tended to be the lowest in atrophic fundal and atrophic pangastritis. They also had significantly elevated concentrations of VIP and glucagon, with insulin decreased. Caused by different exo- and endogenous factors phenomena characteristic of gastritis, such as disturbances in acid-producing function of the stomach, to mention but one of its manifestations, result in changes of stimulatory effects of acidification on enterinic elements of the small intestine, which circumstance leads to discoordination in output of intestinal and pancreatic hormones particularly pronounced in atrophic gastritis.
对112例伴有分泌功能缺陷的慢性胃炎患者和12名基本健康的受试者的血清促胰液素、血管活性肠肽（VIP）、胰高血糖素和胰岛素含量进行了研究。结果表明，在浅表性胃炎、胃底炎和全胃炎中，促胰液素和VIP水平与健康个体的值无差异。促胰液素浓度在萎缩性胃底炎和萎缩性全胃炎中往往最低。这两种胃炎中VIP和胰高血糖素浓度也显著升高，而胰岛素降低。胃炎所特有的由不同外源性和内源性因素引起的现象，如胃产酸功能紊乱（仅提及其中一种表现），会导致酸化对小肠肠内分泌细胞刺激作用的改变，这种情况会导致肠和胰激素分泌失调，在萎缩性胃炎中尤为明显。
