Halpaap K, Horning M G, Horning E C
J Chromatogr. 1978 Dec 11;166(2):479-90. doi: 10.1016/s0021-9673(00)95631-0.
The metabolism of biphenyl in the rat has been studied by using gas chromatographic and mass spectrometric methods. The free and conjugated urinary metabolites were characterized. Eight new metabolites were isolated: a dihydrodiol and two hydroxydihydrodiols were characteristic for the epoxide--diol pathway. There were two dihydroxybiphenyls, a trihydroxybiphenyl, a trihydroxymethoxybiphenyl and 4,4'-dihydroxy-3-methylthiobiphenyl. The mass spectra of the trimethylsilyl derivatives of the metabolites exhibited characteristic doubly charged and metastable ions.
通过气相色谱和质谱法研究了大鼠体内联苯的代谢情况。对游离和结合的尿代谢物进行了表征。分离出了8种新的代谢物：一种二氢二醇和两种羟基二氢二醇是环氧化物-二醇途径的特征性代谢物。还有两种二羟基联苯、一种三羟基联苯、一种三甲氧基三羟基联苯和4,4'-二羟基-3-甲硫基联苯。代谢物的三甲基硅烷基衍生物的质谱显示出特征性的双电荷和亚稳离子。
