Svindland A D, Nordsletten L, Reikerås O, Skjeldal S
Department of Pathology, Ullevål Hospital, University of Oslo, Norway.
Acta Orthop Scand. 1995 Oct;66(5):468-72. doi: 10.3109/17453679508995589.
Complete arrest of blood flow was induced for 4.5 hours in the left hindlimb of Wistar rats by a tourniquet applied proximally to the thigh. Histologically the periost of the tibial bone after 3 days showed marked hypertrophy and hyperplasia of the periosteal cells with an osteogen differentiation. This response is similar to the initial formation of external callus during fracture healing. Transient ischemia may be an important factor in initiating fracture healing.
通过在大腿近端应用止血带，使Wistar大鼠左后肢血流完全阻断4.5小时。组织学检查显示，3天后胫骨骨膜的骨膜细胞显著肥大和增生，并伴有成骨分化。这种反应类似于骨折愈合过程中外骨痂的初始形成。短暂性缺血可能是启动骨折愈合的一个重要因素。
