Cooper T G
Institute of Reproductive Medicine of the University, Münster, Germany.
Adv Exp Med Biol. 1995;377:87-101. doi: 10.1007/978-1-4899-0952-7_6.
This article reviews recent knowledge about events occurring in the epididymis that are important for sperm to fertilise eggs. Well established concepts are stated without references (see Cooper, 1986 for older literature) but recent references are included where they throw light on mechanisms of epididymal function. During their sojourn in the epididymis spermatozoa acquire the capacity to move and to fertilise eggs; they are then stored in a quiescent state prior to ejaculation. The ability of sperm to undergo the events of fertilisation are developed as a result of interactions with certain epididymal secretions. Increases in our knowledge about the genes coding for epididymal secretions has not yet been matched by similar insight into the role that these secretions play in the maturation process. However, information about the changes that occur to the sperm cells during maturation permit certain scenarios to be sketched that may reflect reality. This review is one such attempt to bring the epididymal sperm-epithelial secretion into focus.
本文综述了附睾中发生的对精子使卵子受精至关重要的事件的最新知识。已确立的概念未列出参考文献（较早期文献见Cooper，1986年），但近期参考文献在有助于阐明附睾功能机制的地方列出。精子在附睾中停留期间获得运动和使卵子受精的能力；然后在射精前以静止状态储存。精子进行受精相关事件的能力是与某些附睾分泌物相互作用的结果。我们对编码附睾分泌物的基因的了解有所增加，但对这些分泌物在成熟过程中所起作用的类似深入认识却尚未跟上。然而，关于精子细胞在成熟过程中发生的变化的信息使我们能够勾勒出某些可能反映实际情况的设想。本综述就是将附睾精子 - 上皮分泌纳入关注焦点的一次此类尝试。
