甲状旁腺激素刺激脑突触体中肌醇1,4,5-三磷酸的生成。

Parathyroid hormone stimulates the generation of inositol 1,4,5-triphosphate in brain synaptosomes.

作者信息

Smogorzewski M, Islam A

机构信息

Department of Medicine, University of Southern California, Los Angeles 90033, USA.

出版信息

Am J Kidney Dis. 1995 Nov;26(5):814-7. doi: 10.1016/0272-6386(95)90449-2.

DOI:10.1016/0272-6386(95)90449-2

PMID:7485138

Abstract

Parathyroid hormone (PTH) increases the levels of the second messenger, inositol 1,4,5 triphosphate (I1,4,5P3) in kidney and bone cells. It has been reported the I1,4,5P3 increases calcium uptake by brain synaptosomes. Because PTH also augments calcium entry in brain synaptosomes, it is possible that PTH induces the generation of I1,4,5P3 in these structures as well. The current study examined the effect of PTH-(1-84) on myoinositol turnover in vitro in rat brain synaptosomes. PTH-(1-84) in concentration of 10(-6)mol/L significantly (P < 0.01) increased the IP3 production (35 +/- 52%). The results indicate that PTH activates the phosphoinositol turnover in brain synaptosomes and that this pathway may be involved in the PTH-induced increase in [Ca2+]i in brain synaptosomes.

摘要

甲状旁腺激素（PTH）可提高肾和骨细胞中第二信使肌醇1,4,5 - 三磷酸（I1,4,5P3）的水平。据报道，I1,4,5P3可增加脑突触体对钙的摄取。由于PTH也能增强脑突触体对钙的摄取，因此PTH也有可能在这些结构中诱导I1,4,5P3的生成。本研究检测了PTH - (1 - 84)对大鼠脑突触体肌醇体外周转率的影响。浓度为10(-6)mol/L的PTH - (1 - 84)显著（P < 0.01）增加了IP3的生成（35 +/- 52%）。结果表明，PTH可激活脑突触体中的磷酸肌醇周转率，且该途径可能参与了PTH诱导的脑突触体[Ca2+]i升高。