帕金森病患者亨廷顿病基因中的正常CAG和CCG重复序列。

Normal CAG and CCG repeats in the Huntington's disease genes of Parkinson's disease patients.

作者信息

Rubinsztein D C, Leggo J, Goodburn S, Barton D E, Ferguson-Smith M A

机构信息

East Anglian Regional Genetics Service Molecular Genetics Laboratory, Addenbrooke's NHS Trust, Cambridge, United Kingdom.

出版信息

Am J Med Genet. 1995 Apr 24;60(2):109-10. doi: 10.1002/ajmg.1320600205.

DOI:10.1002/ajmg.1320600205

PMID:7485243

Abstract

The clinical features of Parkinson's disease, particularly rigidity and bradykinesia and occasionally tremor, are seen in juvenile-onset Huntington's disease. Therefore, the CAG and CCG repeats in the Huntington's disease gene were investigated in 45 Parkinson's disease patients and compared to 40 control individuals. All of the Parkinson's disease chromosomes fell within the normal size ranges. In addition, the distributions of the two repeats in the Parkinson's disease patients did not differ significantly from those of the control population. Therefore, abnormalities of these trinucleotide repeats in the Huntington's disease gene are not likely to contribute to the pathogenesis of Parkinson's disease.

摘要

青少年型亨廷顿舞蹈病可出现帕金森病的临床特征，尤其是僵硬、运动迟缓，偶尔也有震颤。因此，对45例帕金森病患者的亨廷顿舞蹈病基因中的CAG和CCG重复序列进行了研究，并与40名对照个体进行比较。所有帕金森病患者的染色体均在正常大小范围内。此外，帕金森病患者中这两种重复序列的分布与对照人群相比无显著差异。因此，亨廷顿舞蹈病基因中这些三核苷酸重复序列的异常不太可能导致帕金森病的发病机制。