Lim L C, Powell J, Sham P, Castle D, Hunt N, Murray R, Gill M
Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, United Kingdom.
Am J Med Genet. 1995 Aug 14;60(4):325-31. doi: 10.1002/ajmg.1320600413.
We present evidence of a genetic association between bipolar disorder and alleles at 3 monoamine oxidase A (MAOA) markers, but not with alleles of a monoamine oxidase B (MAOB) polymorphism. The 3 MAOA markers, including one associated with low MAOA activity, show strong allelic association with each other but surprisingly not with MAOB. Our results are significant only for females, though the number of males in our sample is too small to draw any definite conclusions. Our data is consistent with recent reports of reduced MAOA activity in patients with abnormal behavioral phenotypes. The strength of the association is weak, but significant, which suggests that alleles at the MAOA locus contribute to susceptibility to bipolar disorder rather than being a major determinant.
我们提供了双相情感障碍与3种单胺氧化酶A（MAOA）标记的等位基因之间存在遗传关联的证据，但与单胺氧化酶B（MAOB）多态性的等位基因不存在关联。这3种MAOA标记，包括一种与低MAOA活性相关的标记，彼此之间显示出强烈的等位基因关联，但令人惊讶的是与MAOB没有关联。我们的结果仅对女性具有统计学意义，尽管我们样本中的男性数量太少，无法得出任何明确结论。我们的数据与近期关于行为表型异常患者MAOA活性降低的报道一致。这种关联的强度较弱，但具有统计学意义，这表明MAOA基因座的等位基因有助于双相情感障碍的易感性，而不是主要决定因素。
