多巴胺D1或D2拮抗剂增强胆囊收缩素-8（CCK-8）对 consummatory 摄食行为的抑制作用。
Dopamine D1 or D2 antagonists enhance inhibition of consummatory ingestive behavior by CCK-8.
作者信息
Bednar I, Carrer H, Qureshi G A, Södersten P
机构信息
Department of Clinical Neuroscience, Karolinska Institute, Novum, Huddinge, Sweden.
出版信息
Am J Physiol. 1995 Oct;269(4 Pt 2):R896-903. doi: 10.1152/ajpregu.1995.269.4.R896.
A dopamine D1 (SKF-38393, 1 mg)- or D2 (LY-171555, 0.1 mg)-receptor agonist inhibited intake of an intraorally infused solution of sucrose by male rats, a test of consummatory ingestive behavior. Treatment with a D1 (SCH-39166, 0.1 mg) or D2 (raclopride, 0.6 mg) antagonist reversed inhibition by the respective agonist but enhanced the inhibitory effect of cholecystokinin octapeptide (CCK-8; 1.8 micrograms). It was not possible to demonstrate specific effects of D1 and D2 agonists on intake of pellets, a test that does not discriminate consummatory ingestive behavior from appetitive ingestive behavior, i.e., behavior used to obtain food. The results demonstrate specific involvement of dopamine D1 and D2 receptors in inhibition of consummatory ingestive behavior.
多巴胺D1（SKF - 38393，1毫克）或D2（LY - 171555，0.1毫克）受体激动剂可抑制雄性大鼠经口腔内注入的蔗糖溶液的摄取，这是一种对 consummatory 摄食行为的测试。用D1（SCH - 39166，0.1毫克）或D2（雷氯必利，0.6毫克）拮抗剂处理可逆转相应激动剂的抑制作用，但增强了八肽胆囊收缩素（CCK - 8；1.8微克）的抑制作用。无法证明D1和D2激动剂对颗粒摄取有特定影响，颗粒摄取测试无法区分 consummatory 摄食行为和 appetitive 摄食行为，即用于获取食物的行为。结果表明多巴胺D1和D2受体在抑制 consummatory 摄食行为中具有特定作用。
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