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Antimicrob Agents Chemother. 1995 Aug;39(8):1717-20. doi: 10.1128/AAC.39.8.1717.
2
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Helicobacter pylori comb. nov. Exhibits Facultative Acidophilism and Obligate Microaerophilism.幽门螺旋杆菌组合。新种。表现出兼性嗜酸和严格微需氧性。
Appl Environ Microbiol. 1994 Jun;60(6):2176-9. doi: 10.1128/aem.60.6.2176-2179.1994.
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Pathogenicity of Helicobacter pylori: a perspective.幽门螺杆菌的致病性：一种观点。
Infect Immun. 1993 May;61(5):1601-10. doi: 10.1128/iai.61.5.1601-1610.1993.
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Microbiology of Helicobacter pylori.
Gastroenterol Clin North Am. 1993 Mar;22(1):5-19.
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Hp and pH: implications for the eradication of Helicobacter pylori.幽门螺杆菌与pH值：对根除幽门螺杆菌的影响
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Identification and characterization of an ATPase system of Helicobacter pylori and the effect of proton pump inhibitors.幽门螺杆菌ATP酶系统的鉴定与特性以及质子泵抑制剂的作用
Am J Gastroenterol. 1993 Oct;88(10):1801-2.
6
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.取代苯并咪唑通过阻断（H⁺+K⁺）ATP酶来抑制胃酸分泌。
Nature. 1981 Mar 12;290(5802):159-61. doi: 10.1038/290159a0.
7
Periplasmic phosphatases in Salmonella typhimurium LT2. A biochemical, physiological, and partial genetic analysis of three nucleoside monophosphate dephosphorylating enzymes.鼠伤寒沙门氏菌LT2中的周质磷酸酶。三种单磷酸核苷去磷酸化酶的生化、生理及部分遗传学分析。
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Growth of Campylobacter pylori in liquid media.幽门螺杆菌在液体培养基中的生长
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9
Specific labelling of gastric H+,K+-ATPase by omeprazole.奥美拉唑对胃H⁺，K⁺-ATP酶的特异性标记。
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Microbiological aspects of Helicobacter pylori (Campylobacter pylori).幽门螺杆菌（幽门弯曲菌）的微生物学特性
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利用透化细胞对奥美拉唑对幽门螺杆菌ATP酶活性的部分特性及影响

Partial characterization and effect of omeprazole on ATPase activity in Helicobacter pylori by using permeabilized cells.

作者信息

Belli W A, Fryklund J

机构信息

Department of Cell Biology, Preclinical Research and Development, Astra Hässle AB, Mölndal, Sweden.

出版信息

Antimicrob Agents Chemother. 1995 Aug;39(8):1717-20. doi: 10.1128/AAC.39.8.1717.

DOI:10.1128/AAC.39.8.1717
PMID:7486907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162814/
Abstract

ATPase activity in permeabilized cells of Helicobacter pylori as well as those of Helicobacter felis and Campylobacter jejuni was analyzed. The ATPase activities in these cells were most susceptible to sodium azide, fluoroaluminate, and dicyclohexylcarbodiimide, which are typical inhibitors of F ATPases. Optimal values for maximal activity were found to be at approximately pH 6.4, 6.0, and 6.0 for C. jejuni, H. pylori, and H. felis, respectively. The substituted benzimidazole compounds omeprazole, lansoprazole, and Eisai 3810 were found to have no effect on the F ATPase activity of H. pylori at concentrations which are inhibitory for cell growth (MICs). In addition, an extracellular, vanadate-susceptible ATPase activity was detected in H. pylori, which was also relatively insusceptible to the benzimidazole compounds. Thus, the mechanism of killing mediated by omeprazole and related compounds in Helicobacter pylori does not appear to be due to diminished ATPase activity.

摘要

对幽门螺杆菌以及猫螺杆菌和空肠弯曲菌的透化细胞中的ATP酶活性进行了分析。这些细胞中的ATP酶活性对叠氮化钠、氟铝酸盐和二环己基碳二亚胺最为敏感，它们是F型ATP酶的典型抑制剂。发现空肠弯曲菌、幽门螺杆菌和猫螺杆菌最大活性的最佳值分别约为pH 6.4、6.0和6.0。在对细胞生长具有抑制作用的浓度（最低抑菌浓度）下，发现取代苯并咪唑化合物奥美拉唑、兰索拉唑和卫材3810对幽门螺杆菌的F型ATP酶活性没有影响。此外，在幽门螺杆菌中检测到一种细胞外的、对钒酸盐敏感的ATP酶活性，其对苯并咪唑化合物也相对不敏感。因此，奥美拉唑及相关化合物介导的幽门螺杆菌杀伤机制似乎不是由于ATP酶活性降低。