Azzano O, French P, Robin J, Quinson P, de La Bourdonnaye T, Champsaur G, Mellier G, Normand J, Bozio A
Hôpital cardiologique, BP Lyon-Montchat.
Arch Mal Coeur Vaiss. 1995 Feb;88(2):267-70.
The authors report the case of a woman with thrombosis of a tricuspid Saint Jude prosthesis during the fourth month of pregnancy. A first course of thrombolytic therapy with rt-PA reestablished normal prosthetic valve function but was followed by a threatened abortion and severe uterine haemorrhage. An early rethrombosis of the prosthetic valve led to interruption of the pregnancy after failure of a second course of thrombolysis, and to replacement of the tricuspid valve prosthesis. This case illustrates the problems of pregnancy in women with mechanical cardiac prosthetic valves and the difficulties of treatment.
作者报告了一例在妊娠第四个月时三尖瓣圣犹达人工瓣膜发生血栓形成的女性病例。第一疗程使用重组组织型纤溶酶原激活剂（rt-PA）进行溶栓治疗恢复了人工瓣膜的正常功能，但随后出现了先兆流产和严重的子宫出血。人工瓣膜早期再次血栓形成导致在第二疗程溶栓治疗失败后终止妊娠，并更换了三尖瓣人工瓣膜。该病例说明了患有机械心脏人工瓣膜的女性在妊娠时所面临的问题以及治疗的困难。
