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[心力衰竭中的抗心律失常药物]

[Antiarrhythmia agents in heart failure].

作者信息

Duc P

机构信息

Service de cardiologie, CHU Bichat Claude-Bernard, Paris.

出版信息

Arch Mal Coeur Vaiss. 1995 Apr;88(4 Suppl):595-8.

PMID:7487307
Abstract

Supraventricular and ventricular arrhythmias are extremely common in cardiac failure. No antiarrhythmic agent has been shown to improve survival in atrial fibrillation with left ventricular systolic dysfunction. In symptomatic ventricular tachycardia or fibrillation, treatment is generally determined by the ejection fraction (low EF: amiodarone; intermediate EF: amiodarone and/or betablocker; normal EF: most antiarrhythmics active at ventricular level). In asymptomatic ventricular arrhythmias, the prescription of antiarrhythmic drugs should be restrictive as few studies have demonstrated any benefits and the pro-arrhythmic effects are dangerous. No medication has been shown to be of real value in ventricular tachycardia complicating hypertrophic cardiomyopathy.

摘要

室上性和室性心律失常在心力衰竭中极为常见。尚无抗心律失常药物被证明能改善左心室收缩功能障碍的房颤患者的生存率。对于有症状的室性心动过速或室颤,治疗通常取决于射血分数(射血分数低:胺碘酮;射血分数中等:胺碘酮和/或β受体阻滞剂;射血分数正常:大多数作用于心室水平的抗心律失常药物)。对于无症状的室性心律失常,抗心律失常药物的处方应谨慎,因为很少有研究证明其有任何益处,且促心律失常作用很危险。尚无药物被证明对肥厚型心肌病并发的室性心动过速有实际价值。

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