Niemiałtowski M G, Rouse B T
Department of Microbiology, University of Tennessee, Knoxville 37996-0845, USA.
Arch Immunol Ther Exp (Warsz). 1994;42(4):319-24.
Mice were infected via the cornea with HSV-1. Next, draining lymph nodes (DLN) and spleen cells were analyzed at various times post infection for the presence of cytotoxic T lymphocyte precursors (CTL-p) of both the CD8+ and CD4+ phenotypes. Responses were greatest in the DLN, but memory CTL persisted in the spleen and were undetectable in DLN by 60 days. On all occasions, the frequency of CD8+ CTL outnumbered CD4+ CTL. The murine CTL responses to HSV-1 differ from those in man where CD4+ MHC class II restricted CTL appear to dominate the response at least in the memory phase.
小鼠通过角膜感染单纯疱疹病毒1型（HSV-1）。接下来，在感染后的不同时间分析引流淋巴结（DLN）和脾细胞中CD8 +和CD4 +表型的细胞毒性T淋巴细胞前体（CTL-p）的存在情况。DLN中的反应最为强烈，但记忆性CTL在脾脏中持续存在，到60天时在DLN中无法检测到。在所有情况下，CD8 + CTL的频率均超过CD4 + CTL。小鼠对HSV-1的CTL反应与人不同，在人类中，CD4 + MHC II类限制性CTL似乎至少在记忆阶段主导反应。
