肾细胞癌：肿瘤膜淋巴细胞刺激试验
Renal cell carcinoma: tumor membrane lymphocyte stimulation assay.
作者信息
Hemstreet G P
出版信息
Natl Cancer Inst Monogr. 1978 Dec(49):165-8.
A tumor plasma membrane LSA has been developed to measure cell-mediated immunity in patients with renal cell carcinoma. In this assay system, plasma membranes are adjusted to antigenic equivalence with the use of HLA as a plasma membrane marker. Fifteen patients were studied; 6 of 8 had a significant response to autologous tumor (P less than 0.05). Of 7 patients studied with allogeneic tumor, only 1 was responsive. Various parameters of the tumor membrane LSA are discussed, including dose response, kinetics, and method of data presentation.
已开发出一种肿瘤质膜淋巴细胞刺激活性（LSA）来测量肾细胞癌患者的细胞介导免疫。在该检测系统中，利用人类白细胞抗原（HLA）作为质膜标志物将质膜调整至抗原等价状态。对15名患者进行了研究；8名患者中有6名对自体肿瘤有显著反应（P小于0.05）。在7名接受同种异体肿瘤研究的患者中，只有1名有反应。讨论了肿瘤膜LSA的各种参数，包括剂量反应、动力学和数据呈现方法。
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