[硫酸亚铁胶囊制剂Aktiferrin与速力菲片治疗非复杂性缺铁性贫血患者的有效性和耐受性比较]

[Comparison of the effectiveness and tolerance of Aktiferrin, a ferrous sulfate capsule preparation and Tardyferon pills in patients with uncomplicated sideropenic anemia].

作者信息

Mistrík M, Prümmerová J, Oravská D, Gazová S, Chabronová I, Letkovicová M, Sakalová A

机构信息

Klinika hematológie a transfuziológie FN, Bratislava.

出版信息

Cas Lek Cesk. 1995 Oct 18;134(20):666-8.

PMID:7489584

Abstract

BACKGROUND

The most frequent complications of oral administration of medicinal iron are gastrointestinal complaints the incidence of which correlates with the iron content of the preparation. The objective of the present work was to compare the effectiveness and tolerance of two ferrous sulphate preparations, Aktiferrin capsules and Tardyferon dragées which differ as to the elemental iron content.

METHODS AND RESULTS

To two groups of patients with sideropenic anaemia selected at random (39 women and 1 men, age 14-61 years, median 28 years) Aktiferrin or Tardyferon was administered. Administration of the preparations which have a more than double different elemental iron content had a comparable effect on the investigated haematological parameters. In the group treated with Akiferrin no GIT intolerance was observed, in the group with Tardyferon it was observed in four patients.

CONCLUSIONS

Aktiferrin has a comparable therapeutic effect although it contains 2.5 times less elemental iron, as compared with Tardyferon.

摘要

背景

口服药用铁剂最常见的并发症是胃肠道不适，其发生率与制剂中的铁含量相关。本研究的目的是比较两种硫酸亚铁制剂（Aktiferrin胶囊和Tardyferon糖衣丸）的有效性和耐受性，这两种制剂的元素铁含量不同。

方法与结果

将两组随机选择的缺铁性贫血患者（39名女性和1名男性，年龄14 - 61岁，中位数28岁）分别给予Aktiferrin或Tardyferon。两种制剂的元素铁含量相差两倍多，但对所研究的血液学参数有相似的效果。在接受Aktiferrin治疗的组中未观察到胃肠道不耐受情况，而在接受Tardyferon治疗的组中有4名患者出现了胃肠道不耐受。