Hua H, Yu S, Xu Z
School of Stomatology, Beijing Medical University.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1995 May;30(3):155-7, 192.
Specimens of salivary gland tissue from 21 cases of SS were analyzed by ABC immunohistochemistry technicue with a monoclonal antibody to HLA-DR. The results showed that positive immunostaining for HLA-DR were found in duct cells, acinar cells and a part of infiltrating cells respectively. The proportions of duct and acinar cells expressing HLA-DR were not increased between SS and controls. However, there are differences in their staining intensity. The HLA-DR expression on the epithelial cells in SS was most intense than in controls. Our data suggest that the HLA-DR expression of SS may be regarded as an important factor in local immune rections.
采用抗HLA - DR单克隆抗体，运用ABC免疫组织化学技术对21例干燥综合征患者的唾液腺组织标本进行分析。结果显示，HLA - DR免疫阳性染色分别见于导管细胞、腺泡细胞及部分浸润细胞。干燥综合征患者与对照组相比，表达HLA - DR的导管细胞和腺泡细胞比例未增加。然而，它们的染色强度存在差异。干燥综合征患者上皮细胞上的HLA - DR表达比对照组更强。我们的数据表明，干燥综合征患者的HLA - DR表达可能是局部免疫反应中的一个重要因素。
