Mandelin M, Kajanoja P
Prostaglandins. 1978 Dec;16(6):995-1001. doi: 10.1016/0090-6980(78)90117-x.
The efficiency and acceptability of a single-dose, long-acting vaginal suppository containing 3.0 mg of 15-methyl PGF2alpha methyl ester was compared with intra-amniotic administration of 50 mg of PGF2alpha in 100 patients with a second trimester pregnancy termination. Within 24 hours, 78 per cent of the patients in the vaginal group and 92 per cent in the intra-amniotic group had aborted. The mean induction-abortion interval was 17.9 hours in the vaginal group and 15.8 hours in the intra-amniotic group. Gastrointestinal side-effects were more frequent, but the procedure was less painful, with vaginal 15-methyl PGF2alpha methyl ester than with intra-amniotic PGF2alpha. The vaginal route is technically simple for adaptation to large-scale use, but the high frequency of gastrointestinal side-effects still limits the acceptability of 15-methyl PGF2alpha methyl ester in vaginal administration.
在100例中期妊娠终止患者中，对含3.0毫克15 - 甲基前列腺素F2α甲酯的单剂量长效阴道栓剂与羊膜腔内注射50毫克前列腺素F2α的有效性和可接受性进行了比较。24小时内，阴道给药组78%的患者流产，羊膜腔内给药组92%的患者流产。阴道给药组平均引产 - 流产间隔为17.9小时，羊膜腔内给药组为15.8小时。胃肠道副作用更常见，但使用阴道15 - 甲基前列腺素F2α甲酯的操作疼痛较轻。阴道给药途径技术上简单，便于大规模应用，但胃肠道副作用的高发生率仍然限制了15 - 甲基前列腺素F2α甲酯阴道给药的可接受性。
