Zalupski M M, Baker L H
Division of Hematology and Oncology, Wayne State University, Detroit, Michigan, USA.
Hematol Oncol Clin North Am. 1995 Aug;9(4):787-800.
Adjuvant chemotherapy for soft tissue sarcoma remains investigational. Continued study of multidisciplinary treatment programs in high-grade sarcomas in formal clinical trials remains a priority. The National Cancer Institute is currently conducting a randomized trial of postoperative adjuvant doxorubicin and ifosfamide as compared with observation in high-grade sarcoma. The completion and outcome of this trial will contribute to this ongoing debate. Finally, a better understanding of the biology of soft tissue sarcoma that determines subsequent clinical course may serve as a foundation for further investigation.
软组织肉瘤的辅助化疗仍处于研究阶段。在正式临床试验中继续研究高级别肉瘤的多学科治疗方案仍然是优先事项。美国国立癌症研究所目前正在进行一项随机试验，比较高级别肉瘤术后辅助使用阿霉素和异环磷酰胺与观察的效果。该试验的完成和结果将有助于这场正在进行的辩论。最后，更好地理解决定后续临床病程的软组织肉瘤生物学特性可能为进一步研究奠定基础。
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