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Enantiomeric separation of diltiazem, clentiazem, and its related compounds by capillary electrophoresis using polysaccharides.

作者信息

Nishi H, Terabe S

机构信息

Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.

出版信息

J Chromatogr Sci. 1995 Dec;33(12):698-703. doi: 10.1093/chromsci/33.12.698.

DOI:10.1093/chromsci/33.12.698
PMID:7490300
Abstract

The direct separation of the enantiomers of diltiazem and its three chloro derivatives, including clentiazem, was investigated by capillary zone electrophoresis (CZE) and electrokinetic chromatography (EKC) using polysaccharides. An electrically neutral beta-cyclodextrin polymer, dextran sulfate, and mucopolysaccharides, such as heparin and chondroitin sulfate C, were employed as chiral selectors. Among the tested solutes, 8-chlorodiltiazem (clentiazem) was well enantiorecognized by the methods. Affinity electrokinetic chromatography (AEKC) using chondroitin sulfate C was the most successful; all tested solutes were completely enantioseparated by this mode.

摘要

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