Papastamelos A G, Tunkel A R
University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, USA.
Infect Dis Clin North Am. 1995 Sep;9(3):615-37.
Experimental animal models have provided much information that can be applied to antimicrobial therapy of infections of the central nervous system and eye. The efficacy of an antimicrobial agent in the therapy of meningitis depends upon its ability to penetrate the blood-brain barrier, be active in purulent cerebrospinal fluid, and demonstrate rapid bacterial activity against the offending pathogen. In ocular infections, topically administered drugs must overcome various barriers to penetrate into the eye, or these barriers must be bypassed (i.e., by periocular or intravitreal injection) for optimal therapy. This article reviews the basic therapeutic principles for the treatment of infections of the central nervous system and eye, and gives recommendations for the treatment of specific infections.
实验动物模型已经提供了许多可应用于中枢神经系统和眼部感染抗菌治疗的信息。抗菌药物治疗脑膜炎的疗效取决于其穿透血脑屏障的能力、在脓性脑脊液中的活性以及对致病病原体表现出快速的细菌活性。在眼部感染中，局部给药的药物必须克服各种屏障才能渗透到眼内，或者必须绕过这些屏障（即通过眼周或玻璃体内注射）以实现最佳治疗。本文综述了中枢神经系统和眼部感染治疗的基本治疗原则，并给出了特定感染治疗的建议。
