Sasso F, Gulino G, Basar M, Alcini A, Alcini E
Department of Urology, Catholic University of Sacred Heart, Rome, Italy.
J Urol. 1996 Jan;155(1):150-4.
Due to the lack of a gold standard for performing cavernosometry, we selected 30 patients with veno-occlusive dysfunction to evaluate the internal relationships of cavernosometric parameters and their reliability for therapeutic decisions.
Cavernosometry was performed after injection of 20 to 40 micrograms of prostaglandin E1. Maintenance flow rates, intracavernous pressure decay following cessation of flow and intracavernous pressure changes after compression maneuvers were the main parameters considered.
Cavernosometric results were standardized as grade 1-7 patients with maintenance flow rate less than 20 ml. per minute (mean 18 +/- 2.5) and intracavernous pressure decay 27.5 +/- 15%, grade 2-11 with maintenance flow rates significantly lower (p < 0.001) than grade 1 (mean 37 +/- 11 ml. per minute) and intracavernous pressure decay 33 +/- 20%, and grade 3-12 with only recorded induction flows greater than 70 ml. per minute and intracavernous pressure less than 50 mm. Hg. A strong statistical correlation (p < 0.01) was noted between maintenance flow rate and percent of intracavernous pressure decays.
These parameters allowed us to choose different therapies, such as complex venous surgery, mixed pharmacotherapy or prosthetic implants. Good sexual function was restored in 85% of the cases. We can conclude that our model of standardized cavernosometry has made easier the therapeutic choices in patients who do not respond to intracavernous drugs.
由于缺乏用于海绵体测压的金标准，我们选择了30例静脉闭塞功能障碍患者来评估海绵体测压参数之间的内在关系及其对治疗决策的可靠性。
在注射20至40微克前列腺素E1后进行海绵体测压。主要考虑的参数包括维持流速、停止血流后海绵体内压力衰减以及压迫操作后海绵体内压力变化。
海绵体测压结果被标准化为1级至7级，1级患者维持流速小于每分钟20毫升（平均18±2.5），海绵体内压力衰减为27.5±15%；2级至11级患者维持流速显著低于1级（p<0.001）（平均每分钟37±11毫升），海绵体内压力衰减为33±20%；3级至12级患者仅记录到诱导流速大于每分钟70毫升且海绵体内压力小于50毫米汞柱。维持流速与海绵体内压力衰减百分比之间存在强统计学相关性（p<0.01）。
这些参数使我们能够选择不同的治疗方法，如复杂的静脉手术、联合药物治疗或假体植入。85%的病例恢复了良好的性功能。我们可以得出结论，我们的标准化海绵体测压模型使对海绵体内药物无反应的患者的治疗选择更加容易。
